Mission for Vision
Works on fine needle aspiration biopsy of cancers, benign neoplasms, fluorescent in-situ-hybridization, laser therapy, CT scanning, etc.
Scientific Publications for Lester Layfield, M.D.
Division Chief Anatomic Pathology,
University of Utah.
1. Agatstein, E.H., Hernandez, F.J., Layfield, L.J., Smith, R.B. & deKernion, J.B. Use of fine needle aspiration for detection of stage A prostatic carcinoma before transurethral resection of the prostate: a clinical trial. J Urol 138 , 551-3 (1987).
2. Anders, K. et al. Neuropathologic findings in the acquired immunodeficiency syndrome (AIDS). Clin Neuropathol 5 , 1-20 (1986).
3. Anzai, Y. et al. MR imaging-guided interstitial Nd:YAG laser phototherapy: dosimetry study of acute tissue damage in an in vivo model. J Magn Reson Imaging 1 , 553-9 (1991).
4. Anzai, Y. et al. Nd: YAG interstitial laser phototherapy guided by magnetic resonance imaging in an ex vivo model: dosimetry of laser-MR-tissue interaction. Laryngoscope 101 , 755-60 (1991).
5. Barsky, S.H., Layfield, L., Varki, N. & Bhuta, S. Two human tumors with high basement-membrane-producing potential. Cancer 61 , 1798-806 (1988).
6. Berend, K.R. et al. Association between ratio of matrix metalloproteinase-1 to tissue inhibitor of metalloproteinase-1 and local recurrence, metastasis, and survival in human chondrosarcoma. J Bone Joint Surg Am 80 , 11-7 (1998).
7. Bottles, K. et al. Cytologic criteria used to diagnose adenocarcinoma in pleural effusions. Mod Pathol 4 , 677-81 (1991).
8. Brizel, D.M. et al. Radiation therapy and hyperthermia improve the oxygenation of human soft tissue sarcomas. Cancer Res 56 , 5347-50 (1996).
9. Brizel, D.M. et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res 56 , 941-3 (1996).
10. Brodwater, B.K., Major, N.M., Goldner, R.D. & Layfield, L.J. Macrodystrophia lipomatosa with associated fibrolipomatous hamartoma of the median nerve. Pediatr Surg Int 16 , 216-8 (2000).
11. Castro, D.J. et al. Flexible Nd:YAG laser palliation of obstructive tracheal metastatic malignancies. Laryngoscope 100 , 1208-14 (1990).
12. Castro, D.J. et al. Interstitial laser phototherapy assisted by magnetic resonance imaging: a new technique for monitoring laser-tissue interaction. Laryngoscope 100 , 541-7 (1990).
13. Castro, D.J. et al. Photodynamic therapy using rhodamine-123 as a new laser dye: biodistribution, metabolism and histology in New Zealand rabbits. Laryngoscope 101 , 158-64 (1991).
14. Castro, D.J. et al. Metastatic head and neck malignancy treated using MRI guided interstitial laser phototherapy: an initial case report. Laryngoscope 102 , 26-32 (1992).
15. Cessna, M.H. et al. Are myogenin and myoD1 expression specific for rhabdomyosarcoma? A study of 150 cases, with emphasis on spindle cell mimics. Am J Surg Pathol 25 , 1150-7 (2001).
16. Chai, C., Dodd, L.G., Glasgow, B.J. & Layfield, L.J. Salivary gland lesions with a prominent lymphoid component: cytologic findings and differential diagnosis by fine-needle aspiration biopsy. Diagn Cytopathol 17 , 183-90 (1997).
17. Child, J.S., MacAlpin, R.N., Moyer, G.H., Shanley, J.D. & Layfield, L.J. Coronary ostial embolus and mitral vegetation simulating a left atrial myxoma: a case of probable cryptococcal valvulitis. Clin Cardiol 2 , 43-8 (1979).
18. Coetzee, L.J., Layfield, L.J., Hars, V. & Paulson, D.F. Proliferative index determination in prostatic carcinoma tissue: is there any additional prognostic value greater than that of Gleason score, ploidy and pathological stage? J Urol 157 , 214-8 (1997).
19. Cramer, H., Layfield, L. & Lampe, H. Fine-needle aspiration of salivary glands: its utility and tissue effects. Ann Otol Rhinol Laryngol 102 , 483-5 (1993).
20. Dawsey, S.M., Korn, E.L. & Layfield, L.J. Morphometric analysis of the homogeneity of lymphoid cell populations in fine-needle aspiration cytology smears. Am J Clin Pathol 92 , 458-64 (1989).
21. De Keyser, L., Layfield, L., Van Herle, A., Costin, A. & Lewin, K. Biochemical and immunohistochemical characterization of proteins in Hurthle cell carcinoma. J Endocrinol Invest 7 , 449-54 (1984).
22. Dodd, L.G. & Layfield, L.J. Renal epithelial dysplasia. Am J Surg Pathol 19 , 1335-7 (1995).
23. Dodd, L.G., Farrell, T.A. & Layfield, L.J. Mucinous cystic tumor of the pancreas: an analysis of FNA characteristics with an emphasis on the spectrum of malignancy associated features. Diagn Cytopathol 12 , 113-9 (1995).
24. Dodd, L.G. & Layfield, L.J. Fine-needle aspiration cytology of ganglion cysts. Diagn Cytopathol 15 , 377-81 (1996).
25. Dodd, L.G. & Layfield, L.J. Fine-needle aspiration of inflammatory carcinoma of the breast. Diagn Cytopathol 15 , 363-6 (1996).
26. Dodd, L.G., Moffatt, E.J., Hudson, E.R. & Layfield, L.J. Fine-needle aspiration of primary gallbladder carcinoma. Diagn Cytopathol 15 , 151-6 (1996).
27. Dodd, L.G., Scully, S. & Layfield, L.J. Fine-needle aspiration of epithelioid malignant peripheral nerve sheath tumor (epithelioid malignant schwannoma). Diagn Cytopathol 17 , 200-4 (1997).
28. Dodd, L.G., Kerns, B.J., Dodge, R.K. & Layfield, L.J. Intratumoral heterogeneity in primary breast carcinoma: study of concurrent parameters. J Surg Oncol 64 , 280-7; discussion 287-8 (1997).
29. Dodd, L.G., Mooney, E.E., Layfield, L.J. & Nelson, R.C. Fine-needle aspiration of the liver and pancreas: a cytology primer for radiologists. Radiology 203 , 1-9 (1997).
30. Dodd, L.G., Johnston, W.W., Robertson, C.N. & Layfield, L.J. Endoscopic brush cytology of the upper urinary tract. Evaluation of its efficacy and potential limitations in diagnosis. Acta Cytol 41 , 377-84 (1997).
31. Dodd, L.G., Chai, C., McAdams, H.P. & Layfield, L.J. Fine needle aspiration of osteogenic sarcoma metastatic to the lung. A report of four cases. Acta Cytol 42 , 754-8 (1998).
32. Dresel, S.H. et al. Meckel cave lesions: percutaneous fine-needle-aspiration biopsy cytology. Radiology 179 , 579-82 (1991).
33. Emerson, L., Layfield, L.J., Reiss, R., Mulvihill, S. & Holden, J. Malignant islet cell tumor with sarcomatous differentiation. Mod Pathol 14 , 1187-91 (2001).
34. Emerson, L., Layfield, L.J., Rohr, L.R. & Dayton, M.T. Adenocarcinoma arising in association with gastric heterotopic pancreas: A case report and review of the literature. J Surg Oncol 87 , 53-7 (2004).
35. Fidler, J., Paulson, E.K. & Layfield, L. CT evaluation of acute cholecystitis: findings and usefulness in diagnosis. AJR Am J Roentgenol 166 , 1085-8 (1996).
36. Florell, S.R., Layfield, L.J. & Gerwels, J.W. A comparison of touch imprint cytology and Mohs frozen-section histology in the evaluation of Mohs micrographic surgical margins. J Am Acad Dermatol 44 , 660-4 (2001).
37. Florell, S.R. et al. Novel application of a fibrin cell block method to evaluate melanocytic cell populations. Pigment Cell Res 16 , 662-9 (2003).
38. Fyrat, P. et al. Fine-needle aspiration biopsy of salivary duct carcinoma: report of five cases. Diagn Cytopathol 16 , 526-30 (1997).
39. Glasgow, B.J., Steinsapir, K.D., Anders, K. & Layfield, L.J. Adrenal pathology in the acquired immune deficiency syndrome. Am J Clin Pathol 84 , 594-7 (1985).
40. Glasgow, B.J. et al. Clinical and pathologic findings of the liver in the acquired immune deficiency syndrome (AIDS). Am J Clin Pathol 83 , 582-8 (1985).
41. Glasgow, B.J., Layfield, L.J. & Anders, K.H. Mycobacterium avium-intracellulare and adrenal insufficiency in AIDS. Hum Pathol 19 , 245-6 (1988).
42. Glasgow, B.J. & Layfield, L.J. Fine-needle aspiration biopsy of orbital and periorbital masses. Diagn Cytopathol 7 , 132-41 (1991).
43. Goldstein, N. & Layfield, L.J. Thyromegaly secondary to simultaneous papillary carcinoma and histiocytosis X. Report of a case and review of the literature. Acta Cytol 35 , 422-6 (1991).
44. Goldstein, N.S., Sanford, W., Coffey, M. & Layfield, L.J. Lymph node recovery from colorectal resection specimens removed for adenocarcinoma. Trends over time and a recommendation for a minimum number of lymph nodes to be recovered. Am J Clin Pathol 106 , 209-16 (1996).
45. Goldstein, N.S. et al. E-cadherin reactivity of 95 noninvasive ductal and lobular lesions of the breast. Implications for the interpretation of problematic lesions. Am J Clin Pathol 115 , 534-42 (2001).
46. Gornstein, B. et al. Interobserver agreement of a probabilistic approach to reporting breast fine-needle aspirations on ThinPrep. Diagn Cytopathol 30 , 389-95 (2004).
47. Gritsch, H.A., Randazzo, R.F., Layfield, L.J. & deKernion, J.B. Invasive giant condylomata acuminata: a case report. J Urol 141 , 950-2 (1989).
48. Gupta, D., Shidham, V., Holden, J. & Layfield, L. Prognostic value of immunohistochemical expression of topoisomerase alpha II, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu in adrenal and extra-adrenal pheochromocytomas. Appl Immunohistochem Mol Morphol 8 , 267-74 (2000).
49. Gupta, D.K., Mooney, E.E. & Layfield, L.J. Fine-needle aspiration cytology: a survey of current utilization in relationship to hospital size, surgical pathology volume, and institution type. Diagn Cytopathol 23 , 59-65 (2000).
50. Gupta, D. & Layfield, L.J. Prevalence of inter-institutional anatomic pathology slide review: a survey of current practice. Am J Surg Pathol 24 , 280-4 (2000).
51. Gupta, D., Shidham, V., Holden, J. & Layfield, L. Value of topoisomerase II alpha, MIB-1, p53, E-cadherin, retinoblastoma gene protein product, and HER-2/neu immunohistochemical expression for the prediction of biologic behavior in adrenocortical neoplasms. Appl Immunohistochem Mol Morphol 9 , 215-21 (2001).
52. Gupta, D., Holden, J. & Layfield, L. Topoisomerase alpha II, retinoblastoma gene product, and p53: potential relationships with aggressive behavior and malignant transformation in recurrent respiratory papillomatosis. Appl Immunohistochem Mol Morphol 9 , 86-91 (2001).
53. Gupta, D., Nath, M. & Layfield, L.J. Utility of four-quadrant random sections in mastectomy specimens. Breast J 9 , 307-11 (2003).
54. Hall, T.L., Layfield, L.J., Philippe, A. & Rosenthal, D.L. Sources of diagnostic error in fine needle aspiration of the thyroid. Cancer 63 , 718-25 (1989).
55. Han, M.H. et al. MR-guided aspiration and drainage of a nasopharyngeal mucus retention cyst. AJNR Am J Neuroradiol 12 , 1185-6 (1991).
56. Hart, J. et al. Practical aspects in the diagnosis and management of cystosarcoma phyllodes. Arch Surg 123 , 1079-83 (1988).
57. Hilborne, L.H., Glasgow, B.J. & Layfield, L.J. Fine-needle aspiration cytology of juvenile hemangioma of the parotid gland: a case report. Diagn Cytopathol 3 , 152-5 (1987).
58. Iselin, C.E. et al. Surgical control of clinically localized prostate carcinoma is equivalent in African-American and white males. Cancer 83 , 2353-60 (1998).
59. Jabour, B.A., Lufkin, R.B., Layfield, L.J. & Hanafee, W.N. Magnetic resonance imaging of metastatic cervical adenopathy. Top Magn Reson Imaging 2 , 69-75 (1990).
60. Jensen, R.L., Gillespie, D., House, P., Layfield, L. & Shelton, C. Endolymphatic sac tumors in patients with and without von Hippel-Lindau disease: the role of genetic mutation, von Hippel-Lindau protein, and hypoxia inducible factor-1alpha expression. J Neurosurg 100 , 488-97 (2004).
61. Jones, D.N. et al. Monitoring of neoadjuvant therapy response of soft-tissue and musculoskeletal sarcoma using fluorine-18-FDG PET. J Nucl Med 37 , 1438-44 (1996).
62. Jones, C., Liu, K., Hirschowitz, S., Klipfel, N. & Layfield, L.J. Concordance of histopathologic and cytologic grading in musculoskeletal sarcomas: can grades obtained from analysis of the fine-needle aspirates serve as the basis for therapeutic decisions? Cancer 96 , 83-91 (2002).
63. Kerns, B.J. et al. Determination of proliferation index with MIB-1 in advanced ovarian cancer using quantitative image analysis. Am J Clin Pathol 101 , 192-7 (1994).
64. Kioumehr, F. et al. Wilms tumor (nephroblastoma) in the adult patient: clinical and radiologic manifestations. AJR Am J Roentgenol 152 , 299-302 (1989).
65. Kopald, K.H., Layfield, L.J., Mohrmann, R., Foshag, L.J. & Giuliano, A.E. Clarifying the role of fine-needle aspiration cytologic evaluation and frozen section examination in the operative management of thyroid cancer. Arch Surg 124 , 1201-4; discussion 1204-5 (1989).
66. Krigman, H.R., Iglehart, J.D., Coogan, A.C. & Layfield, L.J. Fine-needle aspiration of low grade adenosquamous carcinoma of the breast. Diagn Cytopathol 14 , 321-4 (1996).
67. Layfield, L.J. Fine needle aspiration cytology of a trabecular adenoma of the parotid gland. Acta Cytol 29 , 999-1002 (1985).
68. Layfield, L.J., Glasgow, B.J. & DuPuis, M.H. Fine-needle aspiration of lymphadenopathy of suspected infectious etiology. Arch Pathol Lab Med 109 , 810-2 (1985).
69. Layfield, L. et al. Neuroendocrine carcinoma of the skin: an immunohistochemical study of tumor markers and neuroendocrine products. J Cutan Pathol 13 , 268-73 (1986).
70. Layfield, L.J., Anders, K.H., Glasgow, B.J. & Mirra, J.M. Fine-needle aspiration of primary soft-tissue lesions. Arch Pathol Lab Med 110 , 420-4 (1986).
71. Layfield, L.J. et al. Cytological grading of prostatic aspiration biopsy: a comparison with the Gleason grading system. J Urol 138 , 798-800 (1987).
72. Layfield, L.J., Tan, P. & Glasgow, B.J. Fine-needle aspiration of salivary gland lesions. Comparison with frozen sections and histologic findings. Arch Pathol Lab Med 111 , 346-53 (1987).
73. Layfield, L.J., Glasgow, B.J., Anders, K.H. & Mirra, J.M. Fine needle aspiration cytology of primary bone lesions. Acta Cytol 31 , 177-84 (1987).
74. Layfield, L.J., Glasgow, B.J., Du Puis, M.H. & Bhuta, S. Aspiration cytology and immunohistochemistry of a pheochromocytoma-ganglioneuroma of the adrenal gland. Acta Cytol 31 , 33-9 (1987).
75. Layfield, L.J., Hilborne, L.H., Ljung, B.M., Feig, S. & Ehrlich, R.M. Use of fine needle aspiration cytology for the diagnosis of testicular relapse in patients with acute lymphoblastic leukemia. J Urol 139 , 1020-2 (1988).
76. Layfield, L.J. & Bhuta, S. Fine-needle aspiration cytology of histiocytosis X: a case report. Diagn Cytopathol 4 , 140-3 (1988).
77. Layfield, L.J. & Ferreiro, J.A. Fine-needle aspiration cytology of chondromyxoid fibroma: a case report. Diagn Cytopathol 4 , 148-51 (1988).
78. Layfield, L.J., Ritchie, A.W. & Ehrlich, R. The relationship of deoxyribonucleic acid content to conventional prognostic factors in Wilms tumor. J Urol 142 , 1040-3 (1989).
79. Layfield, L.J. et al. Relation between DNA ploidy and the clinical behavior of phyllodes tumors. Cancer 64 , 1486-9 (1989).
80. Layfield, L.J. & Ostrzega, N. Fine needle aspirate smear morphology in metastatic melanoma. Acta Cytol 33 , 606-12 (1989).
81. Layfield, L.J., Hall, T.L. & Fu, Y.S. Discrimination of benign versus malignant mixed tumors of the salivary gland using digital image analysis. Cytometry 10 , 217-21 (1989).
82. Layfield, L.J., Glasgow, B.J. & Cramer, H. Fine-needle aspiration in the management of breast masses. Pathol Annu 24 Pt 2 , 23-62 (1989).
83. Layfield, L.J. Fine needle aspiration cytologic findings in a case of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman syndrome). Acta Cytol 34 , 767-70 (1990).
84. Layfield, L.J. & Reichman, A. Fine needle aspiration cytology: utilization in pediatric pathology. Dis Markers 8 , 301-15 (1990).
85. Layfield, L.J., Parkinson, B., Wong, J., Giuliano, A.E. & Bassett, L.W. Mammographically guided fine-needle aspiration biopsy of nonpalpable breast lesions. Can it replace open biopsy? Cancer 68 , 2007-11 (1991).
86. Layfield, L.J. & Fain, J.S. Pleomorphic fibroma of skin. A case report and immunohistochemical study. Arch Pathol Lab Med 115 , 1046-9 (1991).
87. Layfield, L.J. & Lenarsky, C. Desmoplastic small cell tumors of the peritoneum coexpressing mesenchymal and epithelial markers. Am J Clin Pathol 96 , 536-43 (1991).
88. Layfield, L.J., Glasgow, B.J., Goldstein, N. & Lufkin, R. Lipomatous lesions of the parotid gland. Potential pitfalls in fine needle aspiration biopsy diagnosis. Acta Cytol 35 , 553-6 (1991).
89. Layfield, L.J. & Goldstein, N.S. Morphometric analysis of borderline atypia in prostatic aspiration biopsy specimens. Anal Quant Cytol Histol 13 , 288-92 (1991).
90. Layfield, L.J., Mohrmann, R.L., Kopald, K.H. & Giuliano, A.E. Use of aspiration cytology and frozen section examination for management of benign and malignant thyroid nodules. Cancer 68 , 130-4 (1991).
91. Layfield, L.J. Fine needle aspiration cytology of cystic parathyroid lesions. A cytomorphologic overlap with cystic lesions of the thyroid. Acta Cytol 35 , 447-50 (1991).
92. Layfield, L.J. & Lones, M.A. Necrosis in thyroid nodules after fine needle aspiration biopsy. Report of two cases. Acta Cytol 35 , 427-30 (1991).
93. Layfield, L.J. & Glasgow, B.J. Rhabdomyosarcomatous differentiation in a neuroblastoma: a potential pitfall in the cytologic diagnosis of small round-cell tumors of childhood. Diagn Cytopathol 7 , 193-7 (1991).
94. Layfield, L.J. Fine-needle aspiration biopsy in the diagnosis of pediatric tumors. West J Med 154 , 90-1 (1991).
95. Layfield, L.J., Heaps, J.M. & Berek, J.S. Fine-needle aspiration cytology accuracy with palpable gynecologic neoplasms. Gynecol Oncol 40 , 70-3 (1991).
96. Layfield, L.J., Glasgow, B., Ostrzega, N. & Reynolds, C.P. Fine-needle aspiration cytology and the diagnosis of neoplasms in the pediatric age group. Diagn Cytopathol 7 , 451-61 (1991).
97. Layfield, L.J. & Glasgow, B.J. Diagnosis of salivary gland tumors by fine-needle aspiration cytology: a review of clinical utility and pitfalls. Diagn Cytopathol 7 , 267-72 (1991).
98. Layfield, L.J. Can fine-needle aspiration replace open biopsy in the diagnosis of palpable breast lesions? Am J Clin Pathol 98 , 145-7 (1992).
99. Layfield, L.J., Reichman, A., Bottles, K. & Giuliano, A. Clinical determinants for the management of thyroid nodules by fine-needle aspiration cytology. Arch Otolaryngol Head Neck Surg 118 , 717-21 (1992).
100. Layfield, L.J., Reznicek, M., Lowe, M. & Bottles, K. Spontaneous infarction of a parotid gland pleomorphic adenoma. Report of a case with cytologic and radiographic overlap with a primary salivary gland malignancy. Acta Cytol 36 , 381-6 (1992).
101. Layfield, L.J., Robert, M.E., Cramer, H. & Giuliano, A. Aspiration biopsy smear pattern as a predictor of biologic behavior in adenocarcinoma of the breast. Acta Cytol 36 , 208-14 (1992).
102. Layfield, L.J., Reichman, A. & Weinstein, W.M. Endoscopically directed fine needle aspiration biopsy of gastric and esophageal lesions. Acta Cytol 36 , 69-74 (1992).
103. Layfield, L.J. & Glasgow, B.J. Aspiration cytology of clear-cell lesions of the parotid gland: morphologic features and differential diagnosis. Diagn Cytopathol 9 , 705-11; discussion 711-2 (1993).
104. Layfield, L.J. & Glasgow, B.J. Aspiration biopsy cytology of primary cutaneous tumors. Acta Cytol 37 , 679-88 (1993).
105. Layfield, L.J., Chrischilles, E.A., Cohen, M.B. & Bottles, K. The palpable breast nodule. A cost-effectiveness analysis of alternate diagnostic approaches. Cancer 72 , 1642-51 (1993).
106. Layfield, L.J., Armstrong, K., Zaleski, S. & Eckardt, J. Diagnostic accuracy and clinical utility of fine-needle aspiration cytology in the diagnosis of clinically primary bone lesions. Diagn Cytopathol 9 , 168-73 (1993).
107. Layfield, L.J. Focal fatty change of the liver: cytologic findings in a radiographic mimic of metastases. Diagn Cytopathol 11 , 385-7; discussion 387-9 (1994).
108. Layfield, L.J. & Berek, J.S. Fine-needle aspiration cytology in the management of gynecologic oncology patients. Cancer Treat Res 70 , 1-13 (1994).
109. Layfield, L.J., Zaleski, S., Bottles, K. & Cohen, M.B. Laboratory compliance with federal government and professional society recommendations. Diagn Cytopathol 11 , 85-92 (1994).
110. Layfield, L.J. Fine-needle aspiration biopsy of renal collecting duct carcinoma. Diagn Cytopathol 11 , 74-8 (1994).
111. Layfield, L.L., Shopper, T.P. & Weir, J.C. A diagnostic survey of biopsied gingival lesions. J Dent Hyg 69 , 175-9 (1995).
112. Layfield, L.J., Thompson, J.K., Dodge, R.K. & Kerns, B.J. Prognostic indicators for neuroblastoma: stage, grade, DNA ploidy, MIB-1-proliferation index, p53, HER-2/neu and EGFr--a survival study. J Surg Oncol 59 , 21-7 (1995).
113. Layfield, L.J., Wax, T.D., Lee, J.G. & Cotton, P.B. Accuracy and morphologic aspects of pancreatic and biliary duct brushings. Acta Cytol 39 , 11-8 (1995).
114. Layfield, L.J. & Dodd, L.G. Cytologically low grade malignancies: an important interpretative pitfall responsible for false negative diagnoses in fine-needle aspiration of the breast. Diagn Cytopathol 15 , 250-9 (1996).
115. Layfield, L.J., Coogan, A., Johnston, W.W. & Patz, E.F. Transthoracic fine needle aspiration biopsy. Sensitivity in relation to guidance technique and lesion size and location. Acta Cytol 40 , 687-90 (1996).
116. Layfield, L.J. & Dodd, L.G. Fine-needle aspiration of a primary right atrial myxoma. Diagn Cytopathol 14 , 162-4 (1996).
117. Layfield, L.J., Saria, E.A., Conlon, D.H. & Kerns, B.J. Estrogen and progesterone receptor status determined by the Ventana ES 320 automated immunohistochemical stainer and the CAS 200 image analyzer in 236 early-stage breast carcinomas: prognostic significance. J Surg Oncol 61 , 177-84 (1996).
118. Layfield, L.J. Fine-needle aspiration of the head and neck. Pathology (Phila) 4 , 409-38 (1996).
119. Layfield, L.J. et al. Prognostic value of MIB-1 in advanced ovarian carcinoma as determined using automated immunohistochemistry and quantitative image analysis. J Surg Oncol 66 , 230-6; discussion 236-7 (1997).
120. Layfield, L.J., Glasgow, B.J., Hirschcowitz, S. & Dodd, L.G. Intramammary lymph nodes: cytologic findings and implications for fine-needle aspiration cytology diagnosis of breast nodules. Diagn Cytopathol 17 , 223-9 (1997).
121. Layfield, L.J. & Dodd, L.G. Fine-needle aspiration cytology findings in a case of aggressive angiomyxoma: a case report and review of the literature. Diagn Cytopathol 16 , 425-9 (1997).
122. Layfield, L.J., Moffatt, E.J., Dodd, L.G., Scully, S.P. & Harrelson, J.M. Cytologic findings in tenosynovial giant cell tumors investigated by fine-needle aspiration cytology. Diagn Cytopathol 16 , 317-25 (1997).
123. Layfield, L.J. & Dodd, L.G. Cytologic findings in a case of postirradiation angiosarcoma of the breast. Acta Cytol 41 , 612-4 (1997).
124. Layfield, L.J., Mooney, E.E., Glasgow, B., Hirschowitz, S. & Coogan, A. What constitutes an adequate smear in fine-needle aspiration cytology of the breast? Cancer 81 , 16-21 (1997).
125. Layfield, L.J., Saria, E., Mooney, E.E., Liu, K. & Dodge, R.R. Tissue heterogeneity of immunohistochemically detected estrogen receptor. Implications for image analysis quantification. Am J Clin Pathol 110 , 758-64 (1998).
126. Layfield, L.J. Ductal carcinoma in situ of the breast. Hum Pathol 29 , 1329-32 (1998).
127. Layfield, L.J., Liu, K., Dodd, L.G. & Olatidoye, B.A. "Dedifferentiated" chordoma: a case report of the cytomorphologic findings on fine-needle aspiration. Diagn Cytopathol 19 , 378-81 (1998).
128. Layfield, L.J., Liu, K. & Dodge, R.K. Logistic regression analysis of myxoid sarcomas: a cytologic study. Diagn Cytopathol 19 , 355-60 (1998).
129. Layfield, L.J., Mooney, E.E. & Dodd, L.G. Not by blood alone: diagnosis of hemangiomas by fine-needle aspiration. Diagn Cytopathol 19 , 250-4 (1998).
130. Layfield, L.J. & Mooney, E. Fine needle aspiration cytology of poroid hidradenoma. Acta Cytol 42 , 1064-6 (1998).
131. Layfield, L.J. et al. Bone tumor radiograph review by pathologists prior to pathologic diagnosis: a receiver operator curve analysis of diagnostic utility. Oncol Rep 5 , 949-53 (1998).
132. Layfield, L.J. & Mooney, E. Specimen adequacy in FNAB of the breast. Am J Clin Pathol 109 , 494-5 (1998).
133. Layfield, L.J., Liu, K. & Erasmus, J.J. Radiologically-determined diameter, pathologic diameter, and reactive zone surrounding pulmonary neoplasms: implications for transthoracic fine-needle aspiration of pulmonary neoplasms. Diagn Cytopathol 21 , 250-2 (1999).
134. Layfield, L.J., Liu, K. & Dodge, R.K. Logistic regression analysis of small round cell neoplasms: a cytologic study. Diagn Cytopathol 20 , 271-7 (1999).
135. Layfield, L.J., Bentley, R.C. & Mirra, J.M. Pseudoanaplastic giant cell tumor of bone. Arch Pathol Lab Med 123 , 163-6 (1999).
136. Layfield, L.J., Gupta, D. & Mooney, E.E. Assessment of Tissue Estrogen and Progesterone Receptor Levels: A Survey of Current Practice, Techniques, and Quantitation Methods. Breast J 6 , 189-196 (2000).
137. Layfield, L.J. & Mooney, E. Heterotopic Epithelium in an Intramammary Lymph Node. Breast J 6 , 63-67 (2000).
138. Layfield, L.J., Meloni-Ehrig, A., Liu, K., Shepard, R. & Harrelson, J.M. Malignant giant cell tumor of synovium (malignant pigmented villonodular synovitis). Arch Pathol Lab Med 124 , 1636-41 (2000).
139. Layfield, L.J. & Gopez, E.V. Insular carcinoma of the thyroid: report of a case with intact insulae and microfollicular structures. Diagn Cytopathol 23 , 409-13 (2000).
140. Layfield, L.J., Crim, J. & Gupta, D. Fine-needle aspiration findings in nodular myositis: a case report. Diagn Cytopathol 23 , 343-7 (2000).
141. Layfield, L.J. & Goldstein, N.S. Abstracts. Mod Pathol 2000;13:17A,19A,22A,24A,25A,27A. Mod Pathol 13 , 920-1 (2000).
142. Layfield, L.J., Liu, K., Dodge, R. & Barsky, S.H. Uterine smooth muscle tumors: utility of classification by proliferation, ploidy, and prognostic markers versus traditional histopathology. Arch Pathol Lab Med 124 , 221-7 (2000).
143. Layfield, L.J. & Liu, K. Mucoepidermoid carcinoma arising in the glans penis. Arch Pathol Lab Med 124 , 148-51 (2000).
144. Layfield, L.J., Bentz, J.S. & Gopez, E.V. Immediate on-site interpretation of fine-needle aspiration smears: a cost and compensation analysis. Cancer 93 , 319-22 (2001).
145. Layfield, L.J., Cramer, H., Madden, J., Gopez, E.V. & Liu, K. Atypical squamous epithelium in cytologic specimens from the pancreas: cytological differential diagnosis and clinical implications. Diagn Cytopathol 25 , 38-42 (2001).
146. Layfield, L.J. & Gopez, E.V. Cystic lesions of the salivary glands: cytologic features in fine-needle aspiration biopsies. Diagn Cytopathol 27 , 197-204 (2002).
147. Layfield, L.J. & Gopez, E.V. Fine-needle aspiration cytology of giant cell fibroblastoma: case report and review of the literature. Diagn Cytopathol 26 , 398-403 (2002).
148. Layfield, L.J. & Gopez, E.V. Histologic and fine-needle aspiration cytologic features of polycystic disease of the parotid glands: case report and review of the literature. Diagn Cytopathol 26 , 324-8 (2002).
149. Layfield, L.J., Jones, C., Rowe, L. & Gopez, E.V. Institutional review of outside cytology materials: a retrospective analysis of two institutions' experiences. Diagn Cytopathol 26 , 45-8 (2002).
150. Layfield, L.J., Jones, C. & Hirschowitz, S. Statistical analysis of cytologic features useful in separation of metastatic urothelial carcinoma from other metastatic epithelial malignancies. Diagn Cytopathol 29 , 334-8 (2003).
151. Layfield, L.J., Wax, T. & Jones, C. Cytologic distinction of goiterous nodules from morphologically normal thyroid: analyses of cytomorphologic features. Cancer 99 , 217-22 (2003).
152. Layfield, L.J., Bernard, P.S. & Goldstein, N.S. Color multiplex polymerase chain reaction for quantitative analysis of epidermal growth factor receptor genes in colorectal adenocarcinoma. J Surg Oncol 83 , 227-31 (2003).
153. Layfield, L.J., Goldstein, N., Perkinson, K.R. & Proia, A.D. Interlaboratory variation in results from immunohistochemical assessment of estrogen receptor status. Breast J 9 , 257-9 (2003).
154. Layfield, L.J. Cytologic differential diagnosis of myxoid and mucinous neoplasms of the sacrum and parasacral soft tissues. Diagn Cytopathol 28 , 264-71 (2003).
155. Layfield, L.J. & Gopez, E.V. Percutaneous image-guided fine-needle aspiration of peritoneal lesions. Diagn Cytopathol 28 , 6-12 (2003).
156. Layfield, L.J. & Crim, J.R. Dialysis crystalline arthropathy: an entity underrecognized pathologically. Histopathology 44 , 505-7 (2004).
157. Layfield, L.J., Elsheikh, T.M., Fili, A., Nayar, R. & Shidham, V. Review of the state of the art and recommendations of the Papanicolaou Society of Cytopathology for urinary cytology procedures and reporting : the Papanicolaou Society of Cytopathology Practice Guidelines Task Force. Diagn Cytopathol 30 , 24-30 (2004).
158. Layfield, L.J. & Qureshi, M.N. HPV DNA testing in the triage of atypical squamous cells of undetermined significance (ASCUS): cost comparison of two methods. Diagn Cytopathol 33 , 138-43 (2005).
159. Layfield, L.J., Willmore-Payne, C., Shimada, H. & Holden, J.A. Assessment of NMYC amplification: a comparison of FISH, quantitative PCR monoplexing and traditional blotting methods used with formalin-fixed, paraffin-embedded neuroblastomas. Anal Quant Cytol Histol 27 , 5-14 (2005).
160. Layfield, L.J. & Cramer, H. Primary sclerosing cholangitis as a cause of false positive bile duct brushing cytology: report of two cases. Diagn Cytopathol 32 , 119-24 (2005).
161. Layfield, L.J. & Cramer, H. Fine-needle aspiration cytology of intraductal papillary-mucinous tumors: a retrospective analysis. Diagn Cytopathol 32 , 16-20 (2005).
162. Lee, J.G., Leung, J.W., Cotton, P.B., Layfield, L.J. & Mannon, P.J. Diagnostic utility of K-ras mutational analysis on bile obtained by endoscopic retrograde cholangiopancreatography. Gastrointest Endosc 42 , 317-20 (1995).
163. Lee, J.G., Leung, J.W., Baillie, J., Layfield, L.J. & Cotton, P.B. Benign, dysplastic, or malignant--making sense of endoscopic bile duct brush cytology: results in 149 consecutive patients. Am J Gastroenterol 90 , 722-6 (1995).
164. Levitt, S., Cheng, L., DuPuis, M.H. & Layfield, L.J. Fine needle aspiration diagnosis of malignant lymphoma with confirmation by immunoperoxidase staining. Acta Cytol 29 , 895-902 (1985).
165. Lewin, K.J., Layfield, L. & Cheng, L. Disseminated bombesin-producing carcinoid tumor of pulmonary origin. Am J Surg Pathol 9 , 129-34 (1985).
166. Lewin, K.J., Ulich, T., Yang, K. & Layfield, L. The endocrine cells of the gastrointestinal tract. Tumors. Part II. Pathol Annu 21 Pt 2 , 181-215 (1986).
167. Liu, K., Moffatt, E.J., Hudson, E.R. & Layfield, L.J. Gouty tophus presenting as a soft-tissue mass diagnosed by fine-needle aspiration: a case report. Diagn Cytopathol 15 , 246-9 (1996).
168. Liu, K., Layfield, L.J. & Coogan, A.C. Cytologic features of pulmonary metastasis from a granulosa cell tumor diagnosed by fine-needle aspiration: a case report. Diagn Cytopathol 16 , 341-4 (1997).
169. Liu, K., Layfield, L.J. & Krigman, H.R. Cytologic features of a combined tubular adenoma and fibroadenoma of the breast. Diagn Cytopathol 16 , 184-6 (1997).
170. Liu, K., Dodge, R., Glasgow, B.J. & Layfield, L.J. Abstract digest. Diagn Cytopathol 19 , 75-77 (1998).
171. Liu, K., Dodd, L.G. & Layfield, L.J. Fine-needle aspiration of choroidal melanoma metastatic to the liver. Diagn Cytopathol 19 , 155-6 (1998).
172. Liu, K., Dodge, R., Glasgow, B.J. & Layfield, L.J. Fine-needle aspiration: comparison of smear, cytospin, and cell block preparations in diagnostic and cost effectiveness. Diagn Cytopathol 19 , 70-4 (1998).
173. Liu, K., Marshall, J., Shaw, H.S., Dodge, R.K. & Layfield, L.J. Effects of chemotherapy and tamoxifen on cervical and vaginal smears in bone marrow transplant recipients. Acta Cytol 43 , 1027-33 (1999).
174. Liu, K., Dodge, R.K. & Layfield, L.J. Logistic regression analysis of high grade spindle cell neoplasms. A fine needle aspiration cytologic study. Acta Cytol 43 , 593-600 (1999).
175. Liu, K. & Layfield, L.J. Cytomorphologic features of angiosarcoma on fine needle aspiration biopsy. Acta Cytol 43 , 407-15 (1999).
176. Liu, K. et al. Diagnostic accuracy in fine-needle aspiration of soft tissue and bone lesions. Influence of clinical history and experience. Am J Clin Pathol 111 , 632-40 (1999).
177. Liu, K., Dodge, R.K., Dodd, L.G. & Layfield, L.J. Logistic regression analysis of low grade spindle cell lesions. A cytologic study. Acta Cytol 43 , 143-52 (1999).
178. Maguire, P.D. et al. A phase II trial testing the thermal dose parameter CEM43 degrees T90 as a predictor of response in soft tissue sarcomas treated with pre-operative thermoradiotherapy. Int J Hyperthermia 17 , 283-90 (2001).
179. Lo, J., Kerns, B.J., Amling, C.L., Robertson, C.N. & Layfield, L.J. Correlation of DNA ploidy and histologic diagnosis from prostate core-needle biopsies: is DNA ploidy more sensitive than histology for the diagnosis of carcinoma in small specimens? J Surg Oncol 63 , 41-5 (1996).
180. Lufkin, R. & Layfield, L. Coaxial needle system of MR- and CT-guided aspiration cytology. J Comput Assist Tomogr 13 , 1105-7 (1989).
181. Lufkin, R.B. et al. Interventional magnetic resonance imaging in the head and neck. Top Magn Reson Imaging 2 , 76-80 (1990).
182. Macfarlane, M.T., Stein, A., Layfield, L. & deKernion, J.B. Preoperative endoscopic diagnosis of fibroepithelial polyp of the renal pelvis: a case report and review of the literature. J Urol 145 , 549-51 (1991).
183. McDonagh, D.P. et al. Detection of Kaposi's sarcoma-associated herpesvirus-like DNA sequence in angiosarcoma. Am J Pathol 149 , 1363-8 (1996).
184. Moffatt, E.J., Kerns, B.J., Madden, J.M. & Layfield, L.J. Prognostic factors for fibromatoses: a correlation of proliferation index, estrogen receptor, p53, retinoblastoma, and src gene products and clinical features with outcome. J Surg Oncol 65 , 117-22 (1997).
185. Moffatt, E.J., Liu, K. & Layfield, L.J. Demonstration of myxoid change in fine-needle aspiration of synovial sarcoma: a case report. Diagn Cytopathol 18 , 188-91 (1998).
186. Mooney, E.E., Dodd, L.G. & Layfield, L.J. Squamous cells in fine-needle aspiration biopsies of salivary gland lesions: potential pitfalls in cytologic diagnosis. Diagn Cytopathol 15 , 447-52 (1996).
187. Mooney, E.E., Seigler, H.F. & Layfield, L.J. Reporting fine-needle aspirates of breast: a survey of preferences among surgeons. Diagn Cytopathol 19 , 317-20 (1998).
188. Mooney, E.E., Boggess, K.A., Herbert, W.N. & Layfield, L.J. Placental pathology in patients using cocaine: an observational study. Obstet Gynecol 91 , 925-9 (1998).
189. Mooney, E.E. et al. Middle ear carcinoid: an indolent tumor with metastatic potential. Head Neck 21 , 72-7 (1999).
190. Mooney, E.E., Layfield, L.J. & Dodd, L.G. Fine-needle aspiration of neural lesions. Diagn Cytopathol 20 , 1-5 (1999).
191. Mukamel, E., Layfield, L.J., Hawkins, R.A. & Dekernion, J.B. The effect of bacillus Calmette-Guerin on the urinary system of pigs. J Urol 139 , 165-9 (1988).
192. Ostrzega, N., Cheng, L. & Layfield, L.J. Keratin immunoreactivity in fine-needle aspiration of the prostate: an aid in the differentiation of benign epithelium from well-differentiated adenocarcinoma. Diagn Cytopathol 4 , 38-41 (1988).
193. Ostrzega, N., Cheng, L. & Layfield, L. Glial fibrillary acid protein immunoreactivity in fine-needle aspiration of salivary gland lesions: a useful adjunct for the differential diagnosis of salivary gland neoplasms. Diagn Cytopathol 5 , 145-9 (1989).
194. Prose, N.S., Fahrner, L.J., Miller, C.R. & Layfield, L. Pustular psoriasis with chronic recurrent multifocal osteomyelitis and spontaneous fractures. J Am Acad Dermatol 31 , 376-9 (1994).
195. Prosnitz, L.R. et al. The treatment of high-grade soft tissue sarcomas with preoperative thermoradiotherapy. Int J Radiat Oncol Biol Phys 45 , 941-9 (1999).
196. Qureshi, M.N., Rudelli, R.D., Tubbs, R.R., Biscotti, C.V. & Layfield, L.J. Role of HPV DNA testing in predicting cervical intraepithelial lesions: comparison of HC HPV and ISH HPV. Diagn Cytopathol 29 , 149-55 (2003).
197. Raab, S.S. et al. Atypical glandular cells of undetermined significance. Cytologic criteria to separate clinically significant from benign lesions. Am J Clin Pathol 104 , 574-82 (1995).
198. Randall, R.L., Albritton, K.H., Ferney, B.J. & Layfield, L. Malignant fibrous histiocytoma of soft tissue: an abandoned diagnosis. Am J Orthop 33 , 602-8 (2004).
199. Ritchie, A.W., Layfield, L.J., Turcillo, P. & deKernion, J.B. The significance of atypia in fine needle aspiration cytology of the prostate. J Urol 140 , 761-5 (1988).
200. Ritchie, A.W., Layfield, L.J. & deKernion, J.B. Spontaneous regression of liver metastasis from renal carcinoma. J Urol 140 , 596-7 (1988).
201. Ritchie, A.W. et al. Relationship of DNA content to conventional prognostic factors in clinically localised carcinoma of the prostate. Br J Urol 62 , 245-60 (1988).
202. Rohr, L.R., Layfield, L.J., Wallin, D. & Hardy, D. A comparison of routine and rapid microwave tissue processing in a surgical pathology laboratory. Quality of histologic sections and advantages of microwave processing. Am J Clin Pathol 115 , 703-8 (2001).
203. Seeger, L.L., Butler, D.L., Eckardt, J.J., Layfield, L. & Adams, J.S. Tumoral calcinosis-like lesion of the proximal linea aspera. Skeletal Radiol 19 , 579-83 (1990).
204. Sheridan, J.J., McFall, J. & Layfield, L.L. Force-amplified retention for corrected anterior open bites. J Clin Orthod 31 , 817-20 (1997).
205. Sherwin, R.P. & Layfield, L.J. Proteinuria in guinea pigs exposed to 0.5 ppm nitrogen dioxide. Arch Environ Health 28 , 336-41 (1974).
206. Sherwin, R.P. & Layfield, L.J. Protein leakage in the lungs of mice exposed to 0.5 ppm nitrogen dioxide. Arch Environ Health 31 , 116-8 (1976).
207. Stern, R.C., Liu, K., Dodge, R.K., Elenitoba-Johnson, K.S. & Layfield, L.J. Significance of lymphoglandular bodies in bone marrow aspiration smears. Diagn Cytopathol 24 , 240-3 (2001).
208. Tomaszewski, J.E. et al. Consensus conference on second opinions in diagnostic anatomic pathology. Who, What, and When. Am J Clin Pathol 114 , 329-35 (2000).
209. Trapp, T. et al. A new needle and technique for MRI-guided aspiration cytology of the head and neck. Laryngoscope 99 , 105-8 (1989).
210. Tripp, S.R., Willmore-Payne, C. & Layfield, L.J. Relationship between EGFR overexpression and gene amplification status in central nervous system gliomas. Anal Quant Cytol Histol 27 , 71-8 (2005).
211. Turner, R.R., Layfield, L.J., Bishop, P.C., Epstein, A.L. & Parker, J.W. Flow cytometric measurements of proliferation-associated nuclear antigen p105 and DNA content in non-Hodgkin's lymphomas. Arch Pathol Lab Med 113 , 907-11 (1989).
212. Ulich, T.R. et al. Absence of delta antigen in a series of needle biopsies of chronic active hepatitis. Arch Pathol Lab Med 109 , 1061 (1985).
213. Ulich, T.R. & Layfield, L.J. Fatal septic shock after fine needle aspiration of a pancreatic pseudocyst. Acta Cytol 29 , 879-81 (1985).
214. Ulich, T.R., Anders, K., Layfield, L., Cheng, L. & Lewin, K.J. Chronic active hepatitis of hepatitis B and non-A, non-B etiology. Immunohistochemical localization of hepatitis B core antigen in a series of needle biopsies. Arch Pathol Lab Med 109 , 403-7 (1985).
215. Ulich, T.R. et al. Endocrine and tumor differentiation markers in poorly differentiated small-cell carcinoids of the cervix and vagina. Arch Pathol Lab Med 110 , 1054-7 (1986).
216. Valencerina Gopez, E., Dauterman, J. & Layfield, L.J. Fine-needle aspiration biopsy of alveolar rhabdomyosarcoma of the parotid: a case report and review of the literature. Diagn Cytopathol 24 , 249-52 (2001).
217. Vredenburgh, J.J. et al. A comparison of immunohistochemistry, two-color immunofluorescence, and flow cytometry with cell sorting for the detection of micrometastatic breast cancer in the bone marrow. J Hematother 5 , 57-62 (1996).
218. Walker, W.P. et al. Paranuclear blue inclusions in small cell undifferentiated carcinoma: a diagnostically useful finding demonstrated in fine-needle aspiration biopsy smears. Diagn Cytopathol 10 , 212-5 (1994).
219. Wax, T.D. et al. Cytomegalovirus sialadenitis in patients with the acquired immunodeficiency syndrome: a potential diagnostic pitfall with fine-needle aspiration cytology. Diagn Cytopathol 10 , 169-72; discussion 172-4 (1994).
220. Wax, T. & Layfield, L.J. Epithelial-myoepithelial cell carcinoma of the parotid gland: a case report and comparison of cytologic features with other stromal, epithelial, and myoepithelial cell containing lesions of the salivary glands. Diagn Cytopathol 14 , 298-304 (1996).
221. Willmore, C. et al. Detection of c-kit-activating mutations in gastrointestinal stromal tumors by high-resolution amplicon melting analysis. Am J Clin Pathol 122 , 206-16 (2004).
222. Willmore-Payne, C., Holden, J.A., Tripp, S. & Layfield, L.J. Human malignant melanoma: detection of BRAF- and c-kit-activating mutations by high-resolution amplicon melting analysis. Hum Pathol 36 , 486-93 (2005).
223. Willmore-Payne, C., Layfield, L.J. & Holden, J.A. c-KIT mutation analysis for diagnosis of gastrointestinal stromal tumors in fine needle aspiration specimens. Cancer 105 , 165-70 (2005).
224. Layfield and Queresta. Diagnostic Cytopathology 33, 138-143 (2005)