EALES’ DISEASE
Eales’ disease was initially described in young males with vitreous hemorrhage and abnormal retinal veins.[59] Now it is clinically defined by an obliterative vasculopathy involving both venules and arterioles (Figure 7-9).[
60] In the late stages, ischemia leads to neovascularization with resulting vitreous hemorrhage, retinal detachment, and secondary glaucoma.[
61][
62] Specimens are obtained when vitrectomy is done to remove persistent vitreous hemorrhage or extraretinal fibrous tissue.[63] Cytologic specimens may show vitreous hemorrhage (hemoglobin spherulosis) and, occasionally, fibrous tissue (Figure 7-10).
Other conditions that produce neovascularization and vitreous hemorrhage include branch retinal vein occlusion,[
64] sickle cell retinopathy,[
65] carotid and aortic arch occlusive syndromes,[
66] and hyperviscosity syndromes.[
67]
References:
59. Eales H. Cases of retinal hemorrhage associated with epistaxis and constipation. Birm Med Rev 1880;9:262.
60.
Elliot AJ. Thirty-year observation of patients with Eales' disease. Am J Ophthalmol 1975;80:404-408.61.
Renie WA, Murphy RP, Anderson KC, Lippman SM, McKusick VA, et al. The evaluation of patients with Eales' disease. Albrecht Von Graefes Arch Klin Exp Ophthalmol 1975;194:73-85.
62.
Spitznas M, Meryer-Schwickerath GT, Staphan B. The clinical picture of Eales' disease. Albrecht Von Graefes Arch Klin Exp Ophthalmol 1975;194:73-85.
63. Gieser SC, Murphy RP. Eales' disease. In: Ryan SJ, Schachat AP, Murphy RP, Patz A, eds. Retina. St. Louis: C.V. Mosby, 1989;2:535-540.
64.
Heyreh SS, Rojas P, Podhajsky P, Montague P, Woolson RF. Ocular neovascularization with retinal vein occlusion. Ophthalmology 1983;20:488-506. 65.
Goldberg MF. Classifcation and pathogenesis of proliferative sickle retinopathy. Am J Ophthalmol 1971;71:649-665.
66.
Kahn M, Green WR, Knox DL, MIller NR. Ocular features of carotid occlusive disease. Retina 1986;6:239-252.
67.
Ring CP, Pearson TC, Sanders MD, Wetherly Mein G. Viscosity and retinal vein thrombosis. Br J Ophthalmol 1967;60:397-410.
